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CURRICULUM VITAE
VITAE
FOR HONGSHENG
WANG
Name
Hongsheng Wang
Address
N507, Jiuyanlou, North Campus of Sun Yat-sen University, Zhongshan 2 Road #74, Guangzhou,510080, P.R. China
Tel: 86-13751730353, E-mail: whsying@gmail.com
Objective
Ph.D. Degree in ¡°Molecular Pathology; Cancer Biology; Pharmacology¡±
Education
2007-present
Ph.D. candidate
Sun Yat-sen University, P.R. China
Department of Microbiology, Biochemistry and Pharmacology
Supervisor: Professor Jun Du (Nagoya Univ. Japan, 2000)
2003-2007
BS
Sun Yat-sen University, P.R. China
School of Pharmaceutical Science Major in pharmaceutical
Lingnan (University) College
Minor in Finance
Research Experience
10/07-present
Project designer ¡°The construction of pCMV-SB/Arresten and application in
tumor gene therapy¡±.
(Project: We constructed the plasmid using the Sleeping-Beauty transposon to enhance the
security and transfection effective and Arresten gene as the effect endogenetic angiogenesis
inhibitor, then detected the effect in cells and tumor mice model. The project was one of the
top ten medical designs of Sun Yat-sen University, and it got fund supported from the
university education foundation.)
10/07-present
Graduate student, Department of Microbiology , Biochemistry and Pharmacology
Major in: Genetic engineering.
(Supervisor: Jun Du Ph.D.)
07/07-09/07
Leader of the summer holiday program team ¡°The Application of MEKK1
Capped Linearized Vector in EBV Relative Cancer¡±
(Project: First, we constructed the MEKK1 capped linearized vector; then we verified that
MEKK1 capped linearized vector can evoke the suicide gene TK and kill tumor cells with
cooperation of GCV. Advisor: Jun Du Ph.D.)
02/07-07/07
Research Assistant, in the State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center, Sun Yat-sen University, P.R. China. ¡°The Role of
Endoplasmic Reticulum Stress in the Early Stage of Diabetic Retinopathy¡±
(Project: Sprague-Dawley rats were given streptozotocin while nondiabetic control mice
received only buffer. Human retinal capillary endothelial cells were used to examine
expression of vascular endothelial growth factor VEGF, activating transcription factor 4
(ATF4), glucose-regulated protein 78 (GRP78), and C/EBP homologous protein (CHOP).
Advisor: Bin Li Ph.D.)
01/07-06/07
Research Assistant, in the Microbiology, Biochemistry and Pharmacology
laboratory, Sun Yat-sen University P.R. China ¡°MEKK1 evokes the silent of
suicide gene TK in EBV relative tumor cells¡±
(Project: B95-8 cells were transfected pCMV-MEKK1, pCMV-RafS621A£¬pCMV-
RasN17, Akt1 plasmid cooperation with NaB(Sodium butyrate), and results showed that
MEKK1 can evoke the silent of TK and NaB can enhance the sensibility of B95-8 to
GCV(ganciclovir) Advisor: Jun Du Ph.D )
05/06-01/07
Research Assistant. ¡°The Invention of Capped Linearized Vector as a New
General Gene Therapy Vector¡±
(Project: To avoid the security problem of virus vector and low transfection effect of
plasmid vector, the gene expression cassette was capped by special cap then constructed the
capped linearized vector using GFP as report gene. The results of flow cytometry showcapped linerized vector expressed GFP well in eukaryotic cells.)
07/05-09/05
Summer holiday studying program, in the lab of Pharmacology, Sun Yat-sen
University, P.R. China
(Project: Learned some experimental methods such as cell culture, PCR, and Western-
blot, assist a Ph.D. students to do his researches.)
Publications and Patents
1. WANG Hong-Sheng
Hong-Sheng, LI Xiao-Qing, HE Yu-Wen, XIE Bai-Lu, Tang Wen-Ying, Du Jun*, ¡°The Invention of Capped
Linearized Vector as a New General Gene Therapy Vector ¡± Chinese Journal of Biotechnology IF 0.603 (accepted)
2.Hong-sheng Wang
Wang, Yu-wen He, Jun Du*, ¡°The construction of Micro-Linear Vector and application to EBV
Associated Cancer Cells¡± Life Science IF 2.512 (submit)
3. Bin Li, Hong
Hong Sheng Wang
Wang, Gui Gang Li, and Min Hong Zhao ¡°The Role of Endoplasmic Reticulum Stress in the Early
Stage of Diabetic Retinopathy¡± Curr Eye Research IF 1.208 (review)
4. Shi Wei , Hong-sheng Wang
Jia-liang Pan ¡°The relationship between the ACE and physical performance, disease¡±
China sports medicine (review) IF 0.181
5. B. Li, W. Yin, X. Hong, Y. Shi, H.-S.
Wang, S.-F. Lin, and S.-B. Tang ¡°Remodeling Retinal Neovascularization by
ALK1 Gene Transfection In Vitro¡± Invest Ophth Vis Sci IF3.7 ( edited)
6. Chinese patent:Du J, He Y, Wang
Wang H. ¡°The application and constructive approach of a new gene therapy generalvector¡±, Application No. 200710030825. Date:03/10/2007
Honors and Awards
11/07 Top ten medical scientific research designs of Sun Yat-sen University and fund support from Sun Yat-sen
Univ. Research Foundations(£¤1,500)
07/07 Outstanding dissertation of bachelor, Outstanding bachelor graduate(5%)
05/07 Second prizes in Guangdong province, Champion in Sun Yat-sen Univ. ¡°Challenge Cup¡± Contest of
Originality and Innovation,
09/06 The donation scholarship of TianPu Pharmaceutical Limited(1%).
06-07 Two times of fund support from the university education support foundation (£¤1,000*2)
04-07 First class scholarship of Sun Yat-sen Univ. for three continual years.(5%)
(Certificates are available upon request.)
Memberships and
Experiences
1.
Associate secretary of ¡°XVIII International Congress of Eye Research (ICER)¡±, 2007.11-present
2.
Member of ¡°Warm Heart Society¡± to help the poor children faced lose studying, 2006-present
3.
Member of ¡°The Young of Guangzhou Association¡± , as the volunteer for city public, 2007-present4.
Minister of academic department, student union of School of Pharmaceutical Science, 2005-2006
Personality
Hard-working, cooperation, humorous and optimism.
tandardized Tests
GPA in Major: 3.5
GRE: Verbal: 380 26% Qualitative: 800 94%
AW: 3.5 18%
TOEFL:
Total Score:83
(Reading:28 Listening :20 Speaking:17 Writing:18 )
